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KMID : 0363119940070020282
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Korean Journal of Pain
1994 Volume.7 No. 2 p.282 ~ p.286
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Two Cases Report of Epidural Clonidine Analgesia in Cancer Patient and in Patient Tolerant to Opioids
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김병중
김영미/권광준/윤영준/진상호
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Abstract
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the central antihypertensive agent clonidine is an α2-adrenergic agonist that possesses painrelieving properties. It has been administered epidurally in the treatment of cancer pain and for postoperative analgesia.
1) Case 1, 62-year-old woman who suffered from neurogenic pain syndrome due to metastatic squamous cell cardcinoma of spinal canal was treated.
2) Case 2, 51-year-old woman undergoing lower abdominal surgery, epidurally administered morphine did not produced postoperative analgesia.
In these cases, continuous epidural administeration of clonidine (200 ug day) and 0.3% bupivacaine (12 ml/day) produce high quality pain relief.
These results suggest that antinociceptive effect of epidural clonidine is assumed to result from activation of α2-adrenergic receptors in the dorsal horn of the spinal cord.
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KEYWORD
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